[10/27(목) 세미나 안내] Nano-optical Imaging of Biomolecular Behaviors at Abiotic-Biotic Interfaces
- ice
- 조회수1020
- 2022-10-26
1. 제목: Nano-optical Imaging of Biomolecular Behaviors at Abiotic-Biotic Interfaces
2. 일시 및 장소: 10월 27일 목요일 16:00 - 17:00
3. 발표자: 이재규 교수
(Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University)
4. 연사약력:
2021~present Associate Professor
(Seoul National University, Graduate School of Convergence Science and Technology, Department of Applied Bioengineering)
~2021 Research Scientist
(Stanford University, Chemistry)
~2017 Post-doc
(Stanford University, Chemistry)
2011 박사
(University of Southern California, Biomedical Engineering)
2005 석사
(Seoul National University, Biomedical Engineering)
2003 학사
(Seoul National University, Physics)
5. 초록:
This talk will describe two different heterogeneous interfaces as well as the challenge and opportunities arising at the interface. Retinal prosthesis is a biomedical device that was developed to restore the vision loss of blind patients by directly evoking action potentials in retinal ganglion cells. The implanted microelectrode arrays on retinal tissue induce mechanical pressure on the retinal ganglion cells. This mechanical stress occurring at the biotic-abiotic interface induces apoptosis (programmed cell death) in retinal ganglion cells, ultimately limiting the success of the artificial retinal prosthesis. In this talk, I will describe the studies on the molecular origin of cell damage by employing various micro-and nano-techniques, including near-field scanning optical microscopy, live-cell imaging, single-molecular tracking, and microfluidics, as well as systems biology mathematical modeling. Apart from these challenges appearing at the biotic-abiotic interface, the different physicochemical properties arising at the heterogeneous interface allow new scientific and engineering opportunities. The strong intrinsic electric field at the water surface, identified with stimulated Raman excited fluorescence spectroscopy, renders water molecules highly reactive when bulk water is formed into microdroplets. Reactive oxygen species (ROS), including hydrogen peroxide, hydroxyl radical, and superoxide, are spontaneously formed in water microdroplets. We showed that these ROS can be used for green and safe bacterial and viral disinfection. Electrons generated from the spontaneous water oxidation process induce the reduction of gold ions and organic molecules to form the self-assembly of nanostructures. This talk will describe the application of the microdroplet chemistry technique to energy, material, environment, and biomedical issues.